Selective deficiency of IgA

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Selective deficiency of IgA

Definition

Selective deficiency of IgA is the most common immune deficiency disorder. Persons with this disorder have low or absent blood levels of a special protein called immunoglobulin A.

Alternative Names

IgA deficiency

Causes

IgA deficiency is inherited, which means it's passed down through families. It may be inherited as an autosomal dominant or autosomal recessive trait. It is found in approximately 1 in 700 individuals of European origin. It is less common in people of other ethnicities.

References

Azar AE. Evaluation of the adult with suspected immunodeficiency. Am J Med. 2007; 120(9):764-8.

Hoffman R, Benz EJ, Shattil SS, et al. Hematology: Basic Principles and Practice. 4th ed. Orlando, Fl: Churchill Livingstone; 2005.

Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases. 6th ed. London: Churchill Livingstone; 2005.

Morimoto Y. Immunodeficiency Overview. Prim Care. 2008; 35(1):159-7, viii.


Antibodies

Review Date: 5/6/2008
Reviewed By: Stuart I. Henochowicz, MD, FACP. Associate Clinical Professor of Medicine, Division of Allergy, Immunology, and Rheumatology, Georgetown University Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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